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Wallace, Joseph

Joseph Wallace

Education

Bachelor of Science and Engineering
Georgia Tech, 2002

Master of Science and Engineering
Ph.D. Biomedical Engineering

University of Michigan

    About This Team Member

    Joseph is a professor at Indiana University-Purdue University Indianapolis (IUPUI). He graduated from Georgia Tech with a BSE in Aerospace Engineering in 2002 before pursuing an MSE and Ph.D. in Biomedical Engineering from the University of Michigan. His Ph.D. work focused on mechanical and genetic influences on bone structure and function.

    During his first year in the group, Joseph's research focused on quantitatively assessing the internalization and trafficking of polycationic polymer-DNA polyplexes in cells. In September of 2008, he began working under an independent NIH/NRSA F32 Award. This grant is focused on understanding changes that occur in the collagen ultrastructure of bone (as well as dentin and tendon) in mice with the disease Osteogenesis Imperfecta (OI). Using Atomic Force Microscopy (AFM), high resolution imaging of Type I collagen is yielding a wealth of knowledge on how morphological aspects of the tissue ultrastructure contribute to the gross phenotype of mice with OI. Future studies are aimed at developing methods to mechanically probe collagen fibrils as well as extending these methods to larger animal models.

    Publications

    Nanoscale Structure of type I collagen fibrils:  Quantitative measurement of D-spacing

    B. Erickson, M. Fang, J. M. Wallace, B. G. Orr, C. M. Les, M. M. Banaszak Holl
    Biotechnology Journal
    2013
    8
    117-126

    Nanoscale morphology of Type I collagen is altered in the Brtl mouse model of Osteogenesis Imperfecta

    J. M. Wallace, B. G. Orr, J. C. Marini, M. M. Banaszak Holl
    Journal of Structural Biology
    2011,
    173,
    146-152

    Distribution of type I collagen morphologies in bone: Relation to estrogen depletion

    J. M. Wallace, B. Erickson, C. M. Les, B. G. Orr, M. M. Banaszak Holl
    Bone
    2010,
    46,
    1349-1354.

    Type 1 Collagen Exists as a Distribution of Nanoscale Morphologies in Teeth, Bones, and Tendons

    J. M. Wallace, Q. Chen, M. Fang, B. Erickson, B. G. Orr, M. M. Banaszak Holl
    Langmuir
    2010,
    26,
    7349-7354.

    RGD Dendron Bodies: Synthetic Avidity Agents with Defined and Potentially Interchangeable Effector Sites That Can Substitute for Antibodies

    D. Q. McNerny, J. F. Kukowska-Latallo, D. G. Mullen, J. M. Wallace, A. M.Desai, R. Shukla, B. Huang, M. M. Banaszak Holl, J. R. Baker
    Bioconjugate Chemistry
    2009,
    20,
    1853-1859.

    Stoichiometry and Structure of Poly(amidoamine) Dendrimer-Lipid Complexes

    C. V. Kelly, M. G. Liroff, L. D. Triplett, P. R. Leroueil, D. G. Mullen, J. M. Wallace, S. Meschinchi, J. R. Baker, B. G. Orr, M. M. Banaszak Holl
    ACS Nano
    2009
    3,
    1886-1896.