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Vaidyanathan, Sriram

Education

B.S.E.  2011

Purdue University

PhD 2016

University of Michigan

    About This Team Member

    Sriram received his B.S.E in Biomedical Engineering from Purdue University in December 2010. At Purdue, he worked on the controlled release of biomolecules from silica sol gel thin films on microelectrodes under the guidance of Dr. Kevin Otto. He joined the Banaszak Holl group in Fall 2011. He studied non-viral delivery of nucleic acids and the interaction of polymers with biological membranes using an automated microfluidic patch clamp system and a FRET-labeled oligonucleotide probe.  He is currently a post-doctoral associate at Stanford University in the laboratory of Matt Porteus.

     

    Graduation Day!

    Publications

    Cationic Polymer Intercalation into the Lipid Membrane Enables Intact Polyplex DNA Escape from Endosomes for Gene Delivery

    S. Vaidyanathan, J. Chen, B. G. Orr, M. M. Banaszak Holl
    Molecular Pharmaceutics
    2016
    13
    1967-1978

    Increase in Dye:Dendrimer Ratio Decreases Cellular Uptake of Neutral Dendrimers in RAW Cells

    S. Vaidyanathan, M. Kaushik, C. Dougherty, R. Rattan, S. N. Goonewardena, M. M. Banaszak Holl, J. Monano, S. DiMaggio
    ACS Biomaterials Science & Engineering
    2016
    2
    1540-1545

    Role of Cell Membrane-Vector Interactions in Successful Gene Delivery

    S. Vaidyanathan, B. G. Orr, M. M. Banaszak Holl
    Accounts of Chemical Research
    2016
    49
    1486-1493

    Fluorophore:Dendrimer Ratio Impacts Cellular Uptake and Intracellular Fluorescence Lifetime

    C. A. Dougherty, S. Vaidyanathan, B. G. Orr, M. M. Banaszak Holl
    Bioconjugate Chemistry
    2015
    26
    304-315

    Quantitative Measurement of Cationic Polymer Vector and Polymer-pDNA Polyplex Intercalation into the Cell Plasma Membrane

    S. Vaidyanathan, K. B. Anderson, R. L. Merzel, B. Jacobovitz, M. P. Kaushik, C. N. Kelly, M. A. van Dongen, C. A. Dougherty, B. G. Orr, and M. M. Banaszak Holl
    ACS Nano
    2015
    9
    6097-6109

    Detergent Induction of HEK 293A Cell Membrane Permeability Measured under Quiescent and Superfusion Conditions Using Whole Cell Patch Clamp

    S. Vaidyanathan, B. G. Orr. M. M. Banaszak Holl
    Journal of Physical Chemistry B
    2014
    118
    2112-2123

    PAMAM Dendrimers as Quantized Building Blocks for Novel Nanostructures

    M. A. van Dongen, S. Vaidyanathan, M. M. Banaszak Holl
    Soft Matter
    2013
    9
    11188-11196

    Polyplex Exposure Inhibits Cell Cycle, Increases Inflammatory Response, and Can Cause Protein Expression without Cell Division

    R. L. Matz, B Erickson, S. Vaidyanathan, J. F. Kukowska-Latallo, J. R. Baker, B. G. Orr, and M. M. Banaszak Holl
    Molecular Pharmaceutics
    2013
    10
    1306-1317

    Polyplex-Induced Cytosolic Nuclease Activation Leads to Differential Transgene Expression

    R. Rattan, S. Vaidyanathan, G. S.-H. Wu, A. Shakya, B. G. Orr, M. M. Banaszak Holl
    Molecular Pharmaceutics
    2013
    10
    3013-3022