Hong, Seungpyo

About This Team Member

Seungpyo graduated from Hanyang University, Korea with M.S. and B.S. degrees in polymer engineering. His research involved the synthesis of polyorganosilsesquioxanes for microelectronic applications at the Korea Institute of Science and Technology. In 2004, Seungpyo published a set of investigations indicating that nanoparticle can cause nanoscale holes in living cell membranes (Bioconjugate Chemistry 2004, 15, 774-782). Based on these efforts and excellence in course work, Seungpyo won the University of Michigan Overberger Award in 2004 for excellence in polymer research. He then began a series of experiments designed to test the polyvalent effect in the specific targeting of cancer cells. His poster on this work won the "Top Three Best Poster Award" at the fall 2005 MRS meeting. Seungpyo graduated with his PhD in Macromolecular Science and Engineering in 2006 and went on to a post-doc in the Langer lab at MIT. He is now an assistant professor in the Department of Biopharmaceutical Sciences at the University of Illinois - Chicago.

Seungpyo won the 2012 New Investigator Grant Award in Pharmaceutics and Pharmaceutical Technologies from the American Association of Pharmaceutical Scientists.

Publications

Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes

J. Chen, J. A. Hessler, K. Putchakayala, B. K. Panama, D. P. Khan, S. Hong, D. G. Mullen, S. C. DiMaggio, A. Som, G. N. Tew, A. N. Lopatin, J. R. Baker, M. M. Banaszak Holl, B. G. Orr

Journal of Physical Chemistry B

2009,

113,

11179-11185

The Role of Ganglioside GM₁ in Cellular Internalization Mechanisms of Poly(amidoamine) Dendrimers

S. Hong, R. Rattan, I. Majoros, D. G. Mullen, J. L. Peters, X. Shi, A. U. Bielinska, L. Blanco, B. G. Orr. J. R. Baker, M. M. Banaszak Holl

Bioconjugate Chemistry

2009,

20,

1503-1513.

Synthesis, Characterization, and In Vitro Testing of Superparamagnetic Iron Oxide Nanoparticles Targeted Using Folic Acid-Conjugated Dendrimers

K. J. Landmark, S. C. DiMaggio, J. Ward, C. V. Kelly, S. Vogt, S. Hong, A. Kotlyar, J. E. Penner-Hahn, J. R. Baker, Jr., M. M. Banaszak Holl, B. G. Orr

ACS Nano

2008

773-783

Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face?

P. R. Leroueil, S. Hong, A. Mecke, J. R. Baker, Jr., B. G. Orr, M. M. Banaszak Holl

Accounts of Chemical Research

2007

335-342

Nanoparticle-Membrane Interaction: Mechanism for Enhanced Permeability

2007

The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform

S. Hong, P. R. Leroueil, I. Majoros, B. G. Orr, J. R. Baker, Jr., M. M. Banaszak Holl

Chemistry and Biology

2007

107-115

HPLC analysis of functionalized poly(amidoamine) dendrimers and the interaction between a folate-dendrimer conjugate and folate binding protein.

X. Shi, X. Bi, T.R. Ganser, S. Hong, L. A. Myc, A. Desai, M. M. Banaszak Holl, J.R. Baker.

The Analyst

2006,

131,

842-848.

Interaction of Polycationic Polymers with Supported Lipid Bilayers and Cells: Nanoscale Hole Formation and Enhanced Membrane Permeability.

S. Hong, P. R. Leroueil, E. K. Janus, J. L. Peters, M.-M. Kober, M .T. Islam, B. G. Orr, J. R. Baker, Jr., and M. M. Banaszak Holl.

Bioconjugate Chemistry

2006,

17,

728-734.

Physical Interactions of Nanoparticles with Biological Membranes:The Observation of Nanoscale Hole Formation.

S. Hong, J. A. Hessler, M. M. Banaszak Holl, P. Leroueil, A. Mecke, B .G. Orr.

Chemical Health and Safety

2006,

13,

16-20.

The Interaction of Polyamidoamine (PAMAM) Dendrimers with Supported Lipid Bilayers and Cells: Hole Formation and the Relation to Transport.

S. Hong, A. U. Bielinska, A. Mecke, B. Keszler, J. L. Beals, X. Shi, L. Balogh, B. G. Orr, J. R. Baker Jr., and M. M. Banaszak Holl.

Bioconjugate Chemistry

2004,

15,

774-782.

Education

About This Team Member

Publications

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