van Dongen, Mallory
Bachelor of Science
Niagra University, 2009
Doctor of Philosophy
University of Michigan, 2014
About This Team Member
The focus of my graduate work was the challenges in translational applications of nanoparticle based drug delivery systems. My work focused on applications of poly(amidoamine) (PAMAM) dendrimer, which has vast potential as a platform for targeted and multivalent delivery of drugs and imaging agents. I pioneered a project that developed a gram-scalable method to obtain highly pure generation 5 PAMAM free of large, oligomeric by-products. I also developed dendrimer conjugates with precise numbers of biologically functional ligands to study multivalent effects.
Mallory's presentation at the 8th International Dendrimer Symposium won the Polymer Chemistry award.
Her Soft Matter paper in 2013 was featured on the cover and is a 2013 "Hot Article".
Mallory is currently Systems Engineer 3 in the Future Technical Leaders Program at Northrop Grumman Information Systems Division.
Ronny Priefer, Kathryn E. Leach, Todd D. Krauss, Jeanette R. Drapo, Michelle L. Ingalsbe, Mallory A. van Dongen, John C. Cadwalader, Megan A. Baumler, Matthew S. Pinto "Multilayer Film Preparation of PVPh from Aqueous Media" Surface and Coatings Technology, 2008, 202, 6109-6112.
Vincent M. Carroll, Megan A. Baumler, John C. Cadwalader, Jeanette R. Drapo, Michelle L. Ingalsbe, Matthew S. Pinto, Mallory A. van Dongen, Ronny Priefer "Synthesis of Poly(4-vinylphenol) Derivatives and Preparation of Multilayered Films from Aqueous Media" Polymeric Materials: Science and Engineering, 2007, 96, 488-489.
Nonscientific interests: Playing hockey, motorcycling, attending sporting events, reading dystopian fiction
Substrate-Triggered Exosite Binding: Synergistic Dendrimer/Folic Acid Action for Achieving Specific, Tight-Binding to Folate Binding Protein
G5 PAMAM dendrimer versus liposome: A comparison study on the in vitro transepithelial transport and in vivo oral absorption of simvastatin
G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol
Oral Absorption Enhancement of Probucol by PEGylated G5 PAMAM Dendrimer Modified Nanoliposomes
Quantitative Measurement of Cationic Polymer Vector and Polymer-pDNA Polyplex Intercalation into the Cell Plasma Membrane
Avidity Mechanism of Dendrimer-Folic Acid Conjugates
Diffusion NMR Study of Generation-Five PAMAM Dendrimer Materials
Isolation and Characterization of Precise Dye/Dendrimer Ratios
Multivalent Polymers for Drug Delivery and Imaging: The Challenges of Conjugation
Poly(amidoamine) Dendrimer-Methotrexate Conjugates: The Mechanism of Interaction with Folate Binding Protein
The role of caveolin-1 and syndecan-4 in the internalization of PEGylated PAMAM dendrimer polyplexes into myoblast and hepatic cells
Avidity Modulation of Folated-Targeted Multivalent Dendrimers for Evaluating Biophysical Models of Cancer Targeting Nanoparticles
PAMAM Dendrimers as Quantized Building Blocks for Novel Nanostructures
Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer
Best Practices for Purification and Characterization of PAMAM Dendrimer
Efficient in vitro siRNA delivery and Intramuscular Gene Silencing using PEG-Modified PAMAM Dendrimers
Isolation and Characterization of Dendrimers with Precise Numbers of Functional Groups