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van Dongen, Mallory

Education

Bachelor of Science

Niagra University, 2009

Doctor of Philosophy

University of Michigan, 2014

    About This Team Member

    The focus of my graduate work was the challenges in translational applications of nanoparticle based drug delivery systems. My work  focused on applications of poly(amidoamine) (PAMAM) dendrimer, which has vast potential as a platform for targeted and multivalent delivery of drugs and imaging agents. I  pioneered a project that developed a gram-scalable method to obtain highly pure generation 5 PAMAM free of large, oligomeric by-products. I also developed dendrimer conjugates with precise numbers of biologically functional ligands to study multivalent effects.

    Mallory's presentation at the 8th International Dendrimer Symposium won the Polymer Chemistry award.

    Her Soft Matter paper in 2013 was featured on the cover and is a 2013 "Hot Article".

     

    Mallory is currently Systems Engineer 3 in the Future Technical Leaders Program at Northrop Grumman Information Systems Division.

     

     

    Ronny Priefer, Kathryn E. Leach, Todd D. Krauss, Jeanette R. Drapo, Michelle L. Ingalsbe, Mallory A. van Dongen, John C. Cadwalader, Megan A. Baumler, Matthew S. Pinto "Multilayer Film Preparation of PVPh from Aqueous Media" Surface and Coatings Technology, 2008, 202, 6109-6112.

    Vincent M. Carroll, Megan A. Baumler, John C. Cadwalader, Jeanette R. Drapo, Michelle L. Ingalsbe, Matthew S. Pinto, Mallory A. van Dongen, Ronny Priefer "Synthesis of Poly(4-vinylphenol) Derivatives and Preparation of Multilayered Films from Aqueous Media" Polymeric Materials: Science and Engineering, 2007, 96, 488-489.

    Nonscientific interests: Playing hockey, motorcycling, attending sporting events, reading dystopian fiction

     

    Publications

    Substrate-Triggered Exosite Binding: Synergistic Dendrimer/Folic Acid Action for Achieving Specific, Tight-Binding to Folate Binding Protein

    J. Chen, M. A. van Dongen, R. L. Merzel, C. A. Dougherty, A. K. Kandulura, P. S. Low, E. N G. Marsh, M. M. Banaszak Holl
    Biomacromolecules
    2016
    17
    922-927

    G5 PAMAM dendrimer versus liposome: A comparison study on the in vitro transepithelial transport and in vivo oral absorption of simvastatin

    Q. Rong, H. R. Zhang, L. Xu, W.W. Shen, C. Chen, C. Wang, Y. N. Cao, Y. A. Wang, M. A. van Dongen, B. He, S. L. Wang, G. Liu, M. M. Banaszak Holl, Q. Zhang.
    Nanomedicine - Nanotechnology, Biology, and Medicine
    2015
    11
    1141-1151

    G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol

    R. Qi, Y. Z. Li, C. Chen, Y. N. Cao, M. M. Yu, L. Xu, B. He, X. Jie, W. W. Shen, Y. N. Wang, M. A. van Dongen, G. Q. Lui, M. M. Banaszak Holl, Q. Zhang, X. Ke
    Journal of Controlled Release
    2015
    210
    160-168

    Oral Absorption Enhancement of Probucol by PEGylated G5 PAMAM Dendrimer Modified Nanoliposomes

    Q. Ma, Y.C. Han, C. Chen, Y. N. Cao, S. L. Wang, W. W. Shen, H. Y. Zhang, Y. Z. Li, M. A. van Dongen, B. He, M. M. Yu, L. Xu, M. M. Banaszak Holl, G. Liu, Q. Zhang, R. Qi
    Molecular Pharmaceutics
    2015
    12
    665-674

    Quantitative Measurement of Cationic Polymer Vector and Polymer-pDNA Polyplex Intercalation into the Cell Plasma Membrane

    S. Vaidyanathan, K. B. Anderson, R. L. Merzel, B. Jacobovitz, M. P. Kaushik, C. N. Kelly, M. A. van Dongen, C. A. Dougherty, B. G. Orr, and M. M. Banaszak Holl
    ACS Nano
    2015
    9
    6097-6109

    Avidity Mechanism of Dendrimer-Folic Acid Conjugates

    MA van Dongen, JE Silpe, CA Dougherty, AK Kanduluru, SK Choi, BG, Orr, PS Low, MM Banaszak Holl
    Molecular Pharmaceutics
    2014
    11
    1696-1706

    Diffusion NMR Study of Generation-Five PAMAM Dendrimer Materials

    M. A. van Dongen, B. G. Orr, and M. M. Banaszak Holl
    Journal of Physical Chemistry B
    2014
    118
    7195-7202

    Isolation and Characterization of Precise Dye/Dendrimer Ratios

    C. A. Dougherty, J. C. Furgal, M. A. van Dongen, T. Goodson, M. M. Banaszak Holl, J. Manono, S. DiMaggio
    Chemistry a European Journal
    2014
    20
    4638-4645

    Multivalent Polymers for Drug Delivery and Imaging: The Challenges of Conjugation

    M. A. van Dongen, C. A. Dougherty, M. M. Banaszak Holl
    Biomacromolecules
    2014
    15
    3215-3234

    Poly(amidoamine) Dendrimer-Methotrexate Conjugates: The Mechanism of Interaction with Folate Binding Protein

    M. A. van Dongen, R. Rattan, J. Silpe, C. Dougherty, N. L. Michmerhuizen, M. Van Winkle, B. Huang, S.-K. Choi, K. Sinniah, B.G. Orr, M. M. Banaszak Holl
    Molecular Pharmaceutics
    2014
    11
    4049-4058

    The role of caveolin-1 and syndecan-4 in the internalization of PEGylated PAMAM dendrimer polyplexes into myoblast and hepatic cells

    W.W. Shen, M. A. van Dongen, Y.C. Han, M. M. Yu, Y. Z. Li, G. Liu, M. M. Banaszak Holl, R. Qi.
    European Journal of Pharmaceutics and Biopharmaceutics
    2014
    88
    658-663

    Avidity Modulation of Folated-Targeted Multivalent Dendrimers for Evaluating Biophysical Models of Cancer Targeting Nanoparticles

    J. E. Silpe, M. Sumit, T. P. Thomas, B. Huang, A. Kotlyar, M. A. van Dongen, M. M. Banaszak Holl, B. G. Orr, S. K. Choi
    ACS Chemical Biology
    2013
    8
    2063-2071

    PAMAM Dendrimers as Quantized Building Blocks for Novel Nanostructures

    M. A. van Dongen, S. Vaidyanathan, M. M. Banaszak Holl
    Soft Matter
    2013
    9
    11188-11196

    Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer

    M. A. van Dongen, A. Desai, B. G. Orr, J. R. Baker, M. M. Banaszak Holl
    Polymer
    2013
    54
    4126-4133

    Best Practices for Purification and Characterization of PAMAM Dendrimer

    D. G. Mullen, A. Desai, M. A. Van Dongen, M. Barash, J. R. Baker, M. M. Banaszak Holl
    Macromolecules
    2012
    45
    5316-5320

    Efficient in vitro siRNA delivery and Intramuscular Gene Silencing using PEG-Modified PAMAM Dendrimers

    Y. Tang, Y.-B. Li, B. Wang, R.-Y. Lin, M. van Dongen, D. M. Zurcher, X.-Y. Gu, M. M. Banaszak Holl, G. Liu, R. Qi
    Molecular Pharmaceutics
    2012
    9,
    1812-1821

    Isolation and Characterization of Dendrimers with Precise Numbers of Functional Groups

    D. G Mullen, E. L. Borgmeier, A. Desai, M. A. Van Dongen, M. Barash, X.-M. Chen, J. R. Baker, B. G. Orr, M. M. Banaszak Holl
    Chemistry a European Journal
    2010,
    10,
    10675-10678.