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Nanoparticle Toxicity

Folate-Binding Protein Self-Aggregation Drives Agglomeration of Folic Acid Targeted Iron Oxide Nanoparticles

Folate-Binding Protein Self-Aggregation Drives Agglomeration of Folic Acid Targeted Iron Oxide Nanoparticles

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J. Chen, S. Klem, A. K. Jones, B. G. Orr, M. M. Banaszak Holl.
Bioconjugate Chemistry
2017,
28,
81-87.

High-resolution NMR characterization of low abundance oligomers of amyloid

High-resolution NMR characterization of low abundance oligomers of amyloid-beta without purification

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S. Kotler, J. Brender, S. Vivekanandan, Y. Suzuki, K. Yamamoto, M. Monette, J. Krishnamoorthy, P. Walsh, M. Cauble, M. M. Banaszak Holl, E. N. G. Marsh, A. Ramamoorthy.
Scientific Reports
2015,
5,
11811.

Detergent Induction of HEK 293A Cell Membrane Permeability Measured under Quiescent and Superfusion Conditions Using Whole Cell

Detergent Induction of HEK 293A Cell Membrane Permeability Measured under Quiescent and Superfusion Conditions Using Whole Cell Patch Clamp

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S. Vaidyanathan, B. G. Orr. M. M. Banaszak Holl.
Journal of Physical Chemistry B
2014,
118,
2112-2123.

Polyplex Exposure Inhibits Cell Cycle, Increases Inflammatory Response, and Can Cause Protein Expression without Cell Division

Polyplex Exposure Inhibits Cell Cycle, Increases Inflammatory Response, and Can Cause Protein Expression without Cell Division

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R. L. Matz, B Erickson, S. Vaidyanathan, J. F. Kukowska-Latallo, J. R. Baker, B. G. Orr, and M. M. Banaszak Holl.
Molecular Pharmaceutics
2013,
10,
1306-1317.

Solid State NMR Reveals the Hydrophobic-Core Location of Poly(amidoamine) Dendrimers in Biomembranes

Solid State NMR Reveals the Hydrophobic-Core Location of Poly(amidoamine) Dendrimers in Biomembranes

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P. Smith, J. Brender, U. Durr, J. Xu, D. Mullen, M. M. Banaszak Holl, A Ramamoorthy.
J. Am. Chem. Soc.
2010,
132,
8087-8097.

Cationic Poly(amidoamine) Dendrimer Induces Lysosomal Apoptotic Pathway at Therapeutically Relevant Concentrations

Cationic Poly(amidoamine) Dendrimer Induces Lysosomal Apoptotic Pathway at Therapeutically Relevant Concentrations

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T. P. Thomas, I. Majoros, A. Kotlyar, D. Mullen, M. M. Banaszak Holl and J. R. Baker.
Biomacromolecules
2009,
10,
3207–3214.

Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes

Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes

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J. Chen, J. A. Hessler, K. Putchakayala, B. K. Panama, D. P. Khan, S. Hong, D. G. Mullen, S. C. DiMaggio, A. Som, G. N. Tew, A. N. Lopatin, J. R. Baker, M. M. Banaszak Holl, B. G. Orr.
Journal of Physical Chemistry B
2009,
113,
11179-11185.

Stoichiometry and Structure of Poly(amidoamine) Dendrimer-Lipid Complexes

Stoichiometry and Structure of Poly(amidoamine) Dendrimer-Lipid Complexes

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C. V. Kelly, M. G. Liroff, L. D. Triplett, P. R. Leroueil, D. G. Mullen, J. M. Wallace, S. Meschinchi, J. R. Baker, B. G. Orr, M. M. Banaszak Holl.
ACS Nano
2009,
3,
1886-1896.

Nanotoxicology: a personal perspective

Nanotoxicology: a personal perspective. M. M. Banaszak Holl in Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, DOI 10.102/wnan.27

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Interaction of Poly(amidoamine) Dendrimers with Survanta Lung Surfactant: The Importance of Lipid Domains

Interaction of Poly(amidoamine) Dendrimers with Survanta Lung Surfactant:  The Importance of Lipid Domains

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B. Erickson, S. DiMaggio, D. G. Mullen, C. V. Kelly, P. R. Leroueil, S. A. Berry, J. R. Baker, Jr., B. G. Orr, M. M. Banaszak Holl.
Langmuir
2008,
24,
11003-11008.

Poly(amidoamine) dendrimers on lipid bilayers II: Effects of bilayer phase and dendrimer termination

Poly(amidoamine) dendrimers on lipid bilayers II: Effects of bilayer phase and dendrimer termination

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C. V. Kelly, P. R. Leroueil, B. G. Orr, M. M. Banaszak Holl, I. Andricioaei.
Journal of Physical Chemistry B
2008,
112,
9346-9353.

Poly(amidoamine) dendrimers on lipid bilayers I: Free energy and conformation of binding

Poly(amidoamine) dendrimers on lipid bilayers I: Free energy and conformation of binding

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C. V. Kelly, P. R. Leroueil, E. K. Nett, J. M. Wereszczynski, James R. Baker, B. G. Orr, M. M. Banaszak Holl, I. Andricioaei.
Journal of Physical Chemistry B
2008,
112,
9339-9345.

Wide Varieties of Cationic Nanoparticles Induce Defects in Supported Lipid Bilayers

Wide Varieties of Cationic Nanoparticles Induce Defects in  Supported Lipid Bilayers

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P. R. Leroueil, S. A. Berry, K. Duthie, G. Han, V. M. Rotello, D. Q. McNerny, J. R. Baker, Jr.; B. G. Orr, M. M. Banaszak Holl.
Nanoletters
2008,
8,
420-424.

Nanoparticle Interactions with Biological Membranes: A Proposed Physical Mechanism

Nanoparticle Interactions with Biological Membranes: A Proposed Physical Mechanism. J. R. Baker, B. G. Orr, and M. M. Banaszak Holl in "Nanotoxicology: Characterization, Dosing, and Health Effects" ed by Tran and Monteiro-Riviere, Informa Healthcare USA, New York, 2007.

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Nanoparticle-Membrane Interaction: Mechanism for Enhanced Permeability

Nanoparticle-Membrane Interaction: Mechanism for Enhanced Permeability. S. Hong, A. Mecke, P. Leroueil, M. M. Banaszak Holl, and B.G. Orr in "Dendrimer-Based Nanomedicine" co-edited by I.J. Majoros and J.R. Baker, World Scientific Publishing, Hackensack, NJ, 2007.

 

Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face?

Nanoparticle Interaction with Biological Membranes:  Does Nanotechnology Present a Janus Face?

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P. R. Leroueil, S. Hong, A. Mecke, J. R. Baker, Jr., B. G. Orr, M. M. Banaszak Holl .
Accounts of Chemical Research
2007,
40,
335-342.

Interaction of Polycationic Polymers with Supported...

Interaction of Polycationic Polymers with Supported Lipid Bilayers and Cells: Nanoscale Hole Formation and Enhanced Membrane Permeability.

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S. Hong, P. R. Leroueil, E. K. Janus, J. L. Peters, M.-M. Kober, M .T. Islam, B. G. Orr, J. R. Baker, Jr., and M. M. Banaszak Holl.
Bioconjugate Chemistry
2006,
17,
728-734.

Physical Interactions of Nanoparticles with Biological...

Physical Interactions of Nanoparticles with Biological Membranes:The Observation of Nanoscale Hole Formation.

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S. Hong, J. A. Hessler, M. M. Banaszak Holl, P. Leroueil, A. Mecke, B .G. Orr.
Chemical Health and Safety
2006,
13,
16-20.

Lipid Bilayer Disruption by Polyamidoamine Dendrimers:...

Lipid Bilayer Disruption by Polyamidoamine Dendrimers: The Role of Generation and Capping Group.

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A. Mecke, B. G. Orr, M. M. Banaszak Holl, J. R. Baker.
Langmuir
2005,
21,
10348-10354.

Membrane thinning due to antimicrobial peptide binding...

Membrane thinning due to antimicrobial peptide binding -- An AFM study of MSI-78 in DMPC bilayers.

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A. Mecke, D.-K. Kee, A. Ramamoorthy, B. G.Orr, M. M. Banaszak Holl.
Biophysical Journal
2005,
89,
4043-4045.